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Renal impairment CrCl 50 mL/min: Dose adjustment not necessary CrCl 30-50 mL/min: 250-500 mg PO q12hr CrCl 30 mL/min: Extended-release, 500 mg PO q24hr CrCl 5-29 mL/min: 250-500 mg PO q18hr or 200-400 mg IV q18-24hr Some clinicians suggest decreasing dose but not frequency of administration Hemodialysis: 0. domperidone maleate 10 mg 25-0 5 g PO q12hr or 0 2-0 4 g IV